About the instructor:
Event Summary
Dr Sam Jones, PhD, presented a detailed overview of drug development modeling from the perspective of Medicines for Malaria Venture (MMV), an organization focused on reducing the burden of malaria by discovering, developing, and delivering affordable antimalarial drugs. MMV is a global product development partnership that collaborates in over 72 countries worldwide. The presentation emphasized the importance of pharmacokinetics (PK) and pharmacodynamics (PD) in drug optimization. PK models analyze how the body absorbs, distributes, and clears a drug, while PD models describe the drug’s impact on parasites. Together, these models enable predictions on drug efficacy, dose optimization, and potential outcomes. During the talk, Dr. Jones took us through how MMV uses data from in silico, preclinical, to patient confirmatory studies to refine these models, guiding decisions on clinical trials and drug combinations. This modeling approach allows MMV to assess drug and product efficacy early in development and simulate real-world scenarios, providing valuable insights into improving malaria treatment.
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