Sobre o instrutor:
Dr. Tran Dang Nguyen is the founder of the Center for Computational Epidemiology and Infectious Diseases (CEID) in Vietnam, established following his tenure as a Research Assistant Professor at Temple University and PennState University. He earned his Ph.D. from The Open University, UK, in 2016, with a focus on individual-based simulations to combat the spread of antimalarial drug resistance. During his doctoral and postdoctoral work, Dr. Nguyen developed and validated a microsimulation model for malaria, which has been used to evaluate strategies such as multiple first-line therapies, triple artemisinin-based combination therapies (TACTs), and mass drug administration (MDA). His research has informed policy decisions in countries including Uganda, Rwanda, and Tanzania.
Dr. Nawaphan specializes in disease modeling, with expertise in both agent-based and compartmental approaches to support disease control strategies in resource-limited settings. She leverages her background in clinical research and pharmacy to ensure that modeling outputs are practical, policy-relevant, and grounded in real-world application. Nawaphan earned her PhD from the University of Bonn, Germany, with funding from the German government. During her doctoral research, she collaborated closely with the Institute for Disease Modeling (IDM) to evaluate novel gene drive strategies for malaria elimination in the Democratic Republic of the Congo. Prior to her PhD, Nawaphan completed her pharmacy degree and earned master’s degrees in clinical research and business administration from the University of Washington and Imperial College London. She is currently focused on advancing clinical research, health data management, and disease modeling capacity in Southeast Asia.
Resumo do seminário
O grupo AMMNet Asia-Pacific teve o prazer de lançar sua nova série de seminários trimestrais. O seminário contou com duas palestras envolventes dos Drs. Tran Dang Nguyen e Nawaphan Metchanun.
O Dr. Tran Dang Nguyen apresentou os resultados de um modelo matemático baseado em indivíduos que avaliou 53 estratégias para implantar terapias antimaláricas em Uganda para enfrentar a ameaça da malária resistente à artemisinina. O estudo mostrou que mudar para o ASAQ ou implementar várias terapias de primeira linha dominantes no ASAQ poderia ter reduzido significativamente as falhas no tratamento, além de destacar os riscos de resistência associados ao DHA-PPQ. O Dr. Nguyen, fundador do CEID no Vietnã e especialista em epidemiologia computacional, desenvolveu modelos que fundamentaram as decisões políticas de malária em vários países africanos.
O Dr. Nawaphan Metchanun apresentou um estudo que usou modelagem dinâmica de transmissão em nível populacional para prever o impacto da administração de medicamentos em massa com cloroquina (CQ MDA) na malária por P. vivax na sub-região do Grande Mekong. Apesar do progresso da saúde pública, a região continuou enfrentando desafios para eliminar P. vivax, a espécie predominante da malária. A Dra. Nawaphan, especialista em modelagem de doenças compartimentais e baseada em agentes, aplicou sua pesquisa clínica e experiência em farmácia para produzir informações práticas e relevantes para as políticas para o controle da malária em ambientes com recursos limitados.
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